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Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species

Identifieur interne : 003A50 ( Main/Exploration ); précédent : 003A49; suivant : 003A51

Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species

Auteurs : Renate Lüllmann-Rauch [Allemagne] ; Gert-Hinrich Reil [Allemagne]

Source :

Toxicology and Applied Pharmacology [ 0041-008X ] ; 1974.

RBID : ISTEX:AA5FBAF28D1584F5CF7BE5BBA53FB7BFCC353283

English descriptors

Teeft :
- Acta pathol, Adrenal, Adrenal cortex, Adrenal glands, Adrenal medulla, Adrenocortical cell, Alveolar epithelial cells, Alveolar macrophage, Alveolar macrophages, Alveolar spaces, Amphiphilic, Amphiphilic compound, Amphiphilic compounds, Animal wasallowed, Body weights, Cell types, Chlorphentermine, Concentric lamellae, Control animals, Cortical cells, Drug administration, Drug treatment, Foam cells, Generalized phenomenon, Generalized phospholipidosis, Guinea, Guinea pigs, High magnification, Hruban, Inclusion, Intralysosomal accumulation, Lamella, Lamellar, Lamellar bodies, Lamellated, Lysosomal, Lysosomelike bodies, Macrophage, Many inclusions, Matrix, Medullary cells, Numerous lamellated inclusions, Other organs, Other tissues, Paraffin section, Paraffin sections, Pathol, Phospholipidosis, Present study, Pulmonary tissues, Recoverafter cessationof drug treatment, Reil, Retina, Small cubes, Tricyclic antidepressants, Ultrastructural, Ultrastructural alterations, Ultrastructural appearance, Unit membrane, Virchows arch, West germany, Zona, Zona fasciculata, Zona glomerulosa, Zona reticularis.

Abstract

Abstract: Prolonged administration of the anorectic drug chlorphentermine causes an accumulation of “foam cells” in pulmonary alveoli of guinea pigs, mice, and rabbits. Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. In view of the present findings and of the bulk of experimental evidence from the literature, it is concluded that the presence of alveolar “foam cells” in animals treated with an amphiphilic drug is not an isolated occurrence, but rather an indication for a generalized phenomenon, which is believed to be due to a drug-induced phospholipidosis.

Url:

https://api.istex.fr/ark:/67375/6H6-RFWFJH06-H/fulltext.pdf

DOI: 10.1016/0041-008X(74)90263-4

Affiliations:

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Le document en format XML

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<term>Adrenal medulla</term>
<term>Adrenocortical cell</term>
<term>Alveolar epithelial cells</term>
<term>Alveolar macrophage</term>
<term>Alveolar macrophages</term>
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<term>Amphiphilic</term>
<term>Amphiphilic compound</term>
<term>Amphiphilic compounds</term>
<term>Animal wasallowed</term>
<term>Body weights</term>
<term>Cell types</term>
<term>Chlorphentermine</term>
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<term>Control animals</term>
<term>Cortical cells</term>
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<term>Drug treatment</term>
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<term>Other tissues</term>
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<term>Paraffin sections</term>
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<term>Phospholipidosis</term>
<term>Present study</term>
<term>Pulmonary tissues</term>
<term>Recoverafter cessationof drug treatment</term>
<term>Reil</term>
<term>Retina</term>
<term>Small cubes</term>
<term>Tricyclic antidepressants</term>
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<term>Ultrastructural alterations</term>
<term>Ultrastructural appearance</term>
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<term>West germany</term>
<term>Zona</term>
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<term>Zona reticularis</term>
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<front><div type="abstract" xml:lang="en">Abstract: Prolonged administration of the anorectic drug chlorphentermine causes an accumulation of “foam cells” in pulmonary alveoli of guinea pigs, mice, and rabbits. Ultrastructurally, the “foam cells” correspond to enlarged alveolar macrophages, packed with lamellated cytoplasmic inclusions. Lamellar bodies of the same type also occur in increased numbers within nearly all other pulmonary cell types and in the cells of adrenal cortex of all three animal species. These cellular alterations are interpreted to result from an intralysosomal accumulation of phospholipids. In view of the present findings and of the bulk of experimental evidence from the literature, it is concluded that the presence of alveolar “foam cells” in animals treated with an amphiphilic drug is not an isolated occurrence, but rather an indication for a generalized phenomenon, which is believed to be due to a drug-induced phospholipidosis.</div>
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Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species

Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour mettre un lien sur cette page dans le réseau Wicri